Tehran metropolitan with its large population, daily migrant workforce and many students, needs to planning and designing watch/warning system to reduce the climatic problems for human health.for this purpose, we need to study the climate accurately and Since the factors affecting the climate of warm and cold periods in Iran are different, in this study , the meteorological variables of Tehran warm period (May to September 2002) turned into 4 components in Temporal Synoptic Index (TSI) using PCA Method and using P-Array and Varimax rotation.By the scores of components for each day, the clustering method (in ward method) were used and, the warm days of the year was divided into two cluster named favorable and oppressive airmasses. The average maximum air temperature that is more effective in mortality, was 36.13 ° C. Days with temperatures above 34 ° C, less pressure, mild winds , dryness and more sunshine resulted in more adverse weather conditions, which resulted in a 34% increasing in mortality compare with favorable weather. The total number of deaths from cardiovascular disease during the study period was 154046 that about 67%of deaths have been simultaneous with oppressive airmass.The epidemiological study of mortality also confirms the results of previous research in this area and shows that the incidence of mortality is higher in older people as well as in men. It is clear that not all mortality can be attributed to the effects of climate, but results show that change in climatic conditions will affect on mortality and also for study the effect of climatic hazards on human health, it is better that we study the effect of all variables together on humans.